Cell Line Generation for Drug Testing

Back to Cell line engineering >>>
Back to Cell line creation on demand >>>

For drug testing and validation, Creative Cell establishes mammalian cell lines expressing the drug target of interest.

There is a great unmet need to replace in vivo animal testing of compounds with cell line-based in vitro toxicological and efficacy assays. Using its retroviral and lentiviral vector technology, Creative Cell designs, constructs and manufactures cell lines expressing high levels of foreign proteins for drug testing and development applications.

HEK293 cells engineered to express mCherry-tagged hERG, a cardiomyocytic potassium channel. hERG, as an ion channel implicated in the generation of cardiac rhythm, is of major interest for drug testing and development. Blue, nuclei; green, hERG immunostaining; red, mCherry tag. Bottom right: merged image.